Alpha 1 or Alpha-1 may refer to:

• Alpha-1 adrenergic receptor, a G protein-coupled receptor
• Alpha-1 antitrypsin, a protein
  • Alpha-1 antitrypsin deficiency, a genetic disorder
• Alpha-1-fetoprotein or Alpha-fetoprotein, a protein
• Alpha-One, a fictional spacecraft in Buzz Lightyear of Star Command: The Adventure Begins
• Alpha 1 (Robert Silverberg anthology), a 1970 book

See also

• All pages with titles beginning with Alpha 1
• All pages with titles beginning with Alpha-1
• A1 (disambiguation)
• Alpha (disambiguation)
• AMY1A or Alpha-1A or, an enzyme found in humans and other mammals
• List of A1 genes, proteins or receptors