De Sio is a surname of Italian origin. It may refer to:

  • Denise De Sio (b. 1952), Italian-American Lesbian Community leader
  • Giuliana De Sio (b. 1956), Italian actress
  • Teresa De Sio (b. 1955), Italian folk singer-songwriter
  • Vincenzo De Sio (b. 1972), Italian former football player

See also

  • Desio, an Italian municipality in the province of Monza.
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