HSC may stand for:
Business
Computing
- HSC50 (Hierarchical Storage Controller), using DEC Mass Storage Control Protocol
 - Hughes Systique Corporation
 
Medicine
- Health and Social Care in Northern Ireland
 - Hematopoietic stem cell
 - Hepatic stellate cell
 - Hospital for Sick Children, Toronto, Canada
 - Hydraulic Sinus Condensing, a technique used in dentistry to lift the sinus
 - Hysteroscopy, a method for looking into the uterus via the cervix
 
Organizations
Schooling
Certificates
- Higher School Certificate (New South Wales), Australia
 - Higher School Certificate (Victoria), Australia
 - Higher School Certificate (UK)
 - Higher Secondary Certificate (South Asian countries)
 
Schools
- Hampden–Sydney College
 - Hillfield Strathallan College, private school in Hamilton, Ontario, Canada
 - Hsin Sheng College of Medical Care and Management, private junior college in Taoyuan City, Taiwan
 
Related
Other
- High-speed craft
 - Houston Ship Channel
 - Hyper Suprime-Cam, camera for Subaru Telescope
 - Mauser HSc, pistol
 - Shaoguan Guitou Airport, IATA code
 
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