Medieval period

Ordered chronologically

• Hunfrid of Prüm (Saint Humphrey, died 871), Benedictine monk
• Humphrey of Hauteville (c. 1010–1057), Count of Apulia
• Humphrey de Bohun (disambiguation), various people who lived from the 11th to 14th centuries
• Humphrey of Toron (disambiguation), four 12th-century nobles
• Humphrey, 2nd Earl of Buckingham (1381–1399), English peer and member of the House of Lords
• Humphrey, Duke of Gloucester (1390–1447)

Modern era

• Humphrey Atkins (1922–1996), British politician and a member of the Conservative Party
• Humphrey Barclay (1941–), British television comedy producer.
• Humphrey Bate (1875–1936), American harmonica player and string band leader
• Humphrey Bland (1686–1763), British Army general
• Humphrey Bogart (1899–1957), American film actor
• Humphrey Carpenter (1946–2005), English biographer, writer, and radio broadcaster
• Humphrey Critchley-Salmonson (1894–1956), cricketer
• Humphrey Crum-Ewing (1802–1887), English Liberal politician who sat in the House of Commons from 1857 to 1874
• Humphrey J. Desmond (1858–1932), American politician, writer, lawyer, and newspaper editor
• Humphrey Gilbert (1539–1583), English adventurer, explorer, member of parliament and soldier
• Humphrey Henchman (1592–1675), Church of England clergyman and bishop of London from 1663 to 1675
• Humphrey Jennings (1907-1950), English filmmaker and co-founder of Mass-Observation
• Humphrey Lyttelton (1921–2008), British jazz musician and host of I'm Sorry I Haven't a Clue
• Humphrey Mitchell (1894–1950), Canadian politician and trade unionist
• Humphrey Moseley (died 1661), prominent London publisher and bookseller in the middle seventeenth century
• Humphrey Mwanza (1949–2015), Zambian politician
• Humphrey Nyone, Zambian military officer
• Humphrey Owen (1702–1768), Principal of Jesus College, Oxford
• Humphrey Rudge (1977-), Dutch Footballer
• Humphrey Searle (1915–1982), English composer
• Humphrey Wells, former Governor of Georgia
• Humphrey Wingfield (died 1545), English lawyer, Speaker of the House of Commons of England between 1533 and 1536

Arts and entertainment

• Bobbi Humphrey (born 1950), American jazz flautist and singer
• Doris Humphrey (1895–1958), dancer
• Earl Humphrey (1902–1971), American jazz trombonist, brother of Willie and Percy
• Jake Humphrey (born 1978), television presenter
• Maud Humphrey (1868–1940), American illustrator
• Nene Humphrey (born 1947), American artist
• Ozias Humphrey or Humphry (1742–1810), English painter
• Percy Humphrey (1905–1995), American jazz trumpeter, brother of Earl and Willie
• Renee Humphrey (born 1975), American actress
• Scott Humphrey, Canadian record producer and mix engineer
• Willie Humphrey (1900–1994), American jazz clarinetist, brother of Earl and Percy

Politics

• Benjamin G. Humphreys (1808–1882), governor of Mississippi
• Benjamin G. Humphreys II (1865-1923), U.S. Representative from Mississippi
• Charles Humphrey (1792–1850), American lawyer and politician
• Friend Humphrey (1787–1854), New York politician
• Gordon J. Humphrey (born 1940), U.S. senator from New Hampshire
• Hubert Humphrey (1911–1978), Vice President of the United States
• Jasper Humphrey (1812–1892), American sailor and politician
• Lester H. Humphrey (1850–1902), New York state senator
• Muriel Humphrey (1912–1998), U.S. senator from Minnesota and wife of Hubert Humphrey
• Philander P. Humphrey (1823–1862), American politician and physician
• Skip Humphrey (Hubert H. Humphrey III, born 1942), son of Hubert H. Humphrey II
• William E. Humphrey (1862–1934), American politician
• Wolcott J. Humphrey (1817–1890), New York state senator

Sports

• Chris Humphrey (born 1987), footballer
• Claude Humphrey (1944-2021), American former football defensive lineman
• Creed Humphrey (born 1999), American football player
• Lil'Jordan Humphrey (born 1998), American football player
• Marlon Humphrey (born 1996), American football player
• Ryan Humphrey (born 1979), American basketball player
• Tasha Humphrey (born 1985), professional basketball player
• Terin Humphrey (born 1986), American gymnast
• Tory Humphrey (born 1983), American football player

Science and academics

• Heman Humphrey (1779–1861), President of Amherst College
• James Ellis Humphrey (1861-1897), American botanist and mycologist with the botanical author abbreviation Humphrey
• John H. Humphrey (1915-1987), bacteriologist and immunologist
• Nicholas Humphrey (born 1943), British psychologist
• Philip Strong Humphrey (1926–2009), American ornithologist
• Thomas M. Humphrey (born 1935), American economist

Other fields

• Alexander Pope Humphrey (1848–1928), American lawyer, judge of chancery court
• Andrew Humphrey (1921–1977), Marshal of the Royal Air Force
• Edward Porter Humphrey (1809–1886), American Presbyterian minister, author, Presbyterian General Assembly moderator
• Edward William Cornelius Humphrey (1844–1917), American theological and legal scholar
• Hannah Humphrey (active 1745–1818), British publisher and print seller
• John Peters Humphrey (1905–1995), Canadian jurist
• Lewis Craig Humphrey (1875–1927), American newspaper editor
• Mose Humphrey, American and member of Fire Company 40
• Watts Humphrey (1927–2010), American software engineer