A hypothesis is a proposed explanation for a phenomenon.
Hypothesis may also refer to:
- Hypothesis (album), music by Vangelis
 - Hypothesis (drama), in ancient usage, a summary of the plot of a classical drama
 - Hypothesis of a theorem, in mathematics
 - Hypothes.is, a website annotation software
 - Hypothesis Z, the first Romanian war plan for World War I
 
Hypothetical may also refer to:
- Geoffrey Robertson's Hypotheticals, an Australian TV panel show
 - Hypothetical (album), 2001 progressive metal album
 - Hypothetical (TV series), a comedy TV show
 
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