IOC most commonly refers to the International Olympic Committee.
IOC may also refer to:
Computing
- IBM Open Class, IBM C++ product
 - Indicator of compromise (IoC), an artifact likely indicating a computer intrusion
 - Inversion of control (IoC), a software design pattern
 
Other
- Icon of Coil, Norwegian electronic music band
 - Immediate or cancel, a type of order used on some stock exchanges
 - Index of coincidence, In cryptography, the technique of counting the number of times that identical letters appear
 - Indian Ocean Commission, generally COI, but according to World Bank as well IOC
 - Indian Oil Corporation, large Indian oil and gas company
 - Indian Orthodox Church, Kerala, India
 - International Olive Council
 - Initial operating capability, minimum level of deployment, especially in the US military
 - Initiative on Cities, urban research institute at Boston University
 - Initiatives of Change, international organisation "building trust across the world's divides" (formerly Moral Re-Armament)
 - Intergovernmental Oceanographic Commission of Unesco
 - International Oil Company, as opposed to NOC, which stands for National Oil Company
 - International Ornithological Committee, former name of the International Ornithologists' Union
 - International Order of Characters
 - Intraoral camera, a device used to take photos of the inside of a patient's mouth
 - Iron Ore Company of Canada
 - Italian organized crime
 
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