Jefferys is a surname. Notable people with the name include:
- Charles Jefferys (1807–1865), English music publisher and composer
 - Charles William Jefferys (1869–1951), Canadian historical illustrator
 - Eddie Jefferys (fl. 2010s), English music producer
 - Edward Jefferys (1936–1998), South African sprinter
 - John Jefferys (fl. mid-18th century), British game designer
 - John Jefferys (clockmaker) (1701–1754), English horologist
 - Margot Jefferys (1916–1999), British medical sociologist
 - Steve Jefferys, Australian horse trainer, appeared in the 2000 Sydney Olympics Opening Ceremony
 - Thomas Jefferys (c. 1719–1771), English cartographer
 - William H. Jefferys (born 1940), American astronomer
 
See also
- Jefferys Allen (1760–1844), British politician, MP for Bridgwater
 - Jefferies
 
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