Josephson is a patronymic surname meaning "son of Joseph". Notable people with the surname include:
- Andy Josephson (born 1964), American lawyer and politician
 - Brian David Josephson (born 1940), Welsh physicist
 - Duane Josephson (1942–1997), American baseball player
 - Erland Josephson (1923–2012), Swedish actor and author
 - Erik Josephson (1864–1929), Swedish architect
 - Ernst Josephson (1851–1906), Swedish painter
 - Ian Josephson, Canadian judge
 - Julien Josephson (1881–1959), American motion picture screenwriter
 - Karen Josephson (born 1964), American swimmer
 - Les Josephson (1942–2020), American football player
 - Mark Josephson (1943–2017), American cardiac electrophysiologist
 - Matthew Josephson (1899–1978), American journalist and author
 - Samantha Josephson (died 2019), American murder victim
 - Sarah Josephson (born 1964), American swimmer
 - Timothy Josephson, American politician
 
See also
- Josephson effect, used in quantum-mechanical circuits, with related terms:
 - Josefsson
 - Hans Josephsohn (1920–2012), Swiss sculptor
 
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