Mullen is a surname of Irish origin. Notable people with the surname include:
- Alex Mullen (born 1992), Australian professional footballer
 - Andrew Mullen (born 1996), British Paralympian swimmer
 - Ann A. Mullen (1935–1994), American politician
 - April Mullen, Canadian actress and filmmaker
 - Barbara Mullen (1914–1979), American actress
 - Brian Mullen (born 1962), former NHL player
 - Charlie Mullen (1889–1963), Major League Baseball first baseman
 - Conor Mullen (born 1962), Irish actor
 - Dan Mullen (born 1972), American college football coach
 - Danny Mullen (born 1995), Scottish professional footballer
 - David Mullen (photographer) (born 1952), artist and photographer
 - David Mullen (singer) (born 1964), former Blues Pop / CCM singer and producer
 - Earl Mullen (1902–1969), American politician and businessman
 - Ed Mullen (1913–1988), American professional basketball player
 - Frank Mullen, American death metal vocalist
 - Fraser Mullen (born 1993), professional footballer
 - Geoff Mullen (1947–2014), Australian draft resister
 - George Mullen (born 1974), art historian, gallery owner and auctioneer in Berlin
 - Graham Calder Mullen (born 1940), Senior United States District Judge
 - Harryette Mullen (born 1953), American poet, author and professor of English
 - James T. Mullen (1843–1891), first Supreme Knight of the Knights of Columbus
 - Jarrod Mullen (born 1987), current NRL player
 - Jeff Mullen (born c. 1968), assistant football coach for West Virginia University
 - Jerry Mullen (1933–1979), college basketball player (San Francisco)
 - Jesse James Mullen (born c. 1984), businessman and politician in Montana
 - Jim Mullen (born 1945), Scottish jazz guitarist
 - Jimmy Mullen (footballer born 1923) (1923–1987), football player
 - Jimmy Mullen (footballer born 1952) (born 1952), former football player and manager
 - Joe Mullen (born 1957), former NHL player
 - John Joseph Mullen (1829–1897), member of the Queensland Legislative Council
 - John Mullan (academic), professor of English at University College London
 - Karl Mullen (1926–2009), Irish Rugby Union player
 - Kathryn Mullen (born 1940), American puppeteer, actress, and voice actress
 - Keith Mullen (born 1961), English rock musician
 - Larry Mullen, Jr., (born 1961), drummer for U2
 - Laura Mullen (born 1958), American poet
 - Luke Mullen (born 2001), American actor, filmmaker, and environmentalist
 - M. David Mullen (born 1962), Japanese-born American cinematographer
 - Madeleine ffrench-Mullen (1880–1944), Irish revolutionary and labour activist
 - Marie Mullen (born 1953), Irish actress
 - Mark Mullen (born 1961), NBC News Chief and Reporter
 - Matthew Mullen (born 1989), Australian footballer
 - Michael Mullen (1919–1982), Irish Labour Party politician and trade union official
 - Michael Mullen (born 1946), United States Navy admiral and Chairman of the Joint Chiefs of Staff for the US military
 - Michael Mullen (born 1958), professional investment analyst and associate professor of finance at Stonehill College
 - Moon Mullen (1917–2013), American baseball player
 - Nick Mullen (born 1988), American comedian
 - Nicole C. Mullen (born 1967), American singer, songwriter, and choreographer
 - Patrick Mullen (ice hockey) (born 1986), American ice hockey player
 - Patrick Mullen (Medal of Honor) (1844–1897), member of the United States Navy
 - Paul Mullen (rugby union) (born 1991), Irish-born rugby union player
 - Paul Mullen (born 1982), English multi-instrumentalist and singer-songwriter
 - Peg Mullen (1917–2009), American anti-war activist
 - Peter Mullen (born 1942), British Church of England priest and Rector of St Michael, Cornhill
 - Rodney Mullen (born 1966), professional skateboarder
 - Rónán Mullen (born 1970), Irish politician
 - Ruth González Mullen (1939–2009), Cuban artist
 - Ryan Grice-Mullen (born 1986), former gridiron football wide receiver
 - Ryan Mullen (born 1994), Irish professional racing cyclist
 - Samuel Mullen (1828–1890), Irish bookseller in Australia
 - Sheila Mullen (artist) (born 1942), Scottish painter
 - Sheila Mullen (model) (born 1957), American model
 - Thomas Mullen (1897–1966), Irish Fianna Fáil politician and school teacher
 - Tiawan Mullen (born 2000), American football player
 - Tobias Mullen (1818–1900), Roman Catholic Bishop of Erie
 - Tom Mullen (born 1951), American football player
 - Trayvon Mullen (born 1997), American football player
 - William F. Mullen, III, United States Marine Corps officer
 - Len Mullen, Glasgow Scotland, Professional Boxer
 
See also
- Mac Maoláin, a surname
 - Maelan mac Cathmogha, a king
 - Moylan, a surname
 - Mullenising, an Australian scrub-clearing device
 - Mullens (disambiguation)
 - Mullin, a surname
 - Mullins (surname)
 
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