PKA may refer to:
- Napaskiak Airport (IATA code), airport in Napaskiak, Alaska
 - Professionally known as:
 - pKa, the symbol for the acid dissociation constant at logarithmic scale
 - Protein kinase A, a class of cAMP-dependent enzymes
 - Pi Kappa Alpha, the North-American social fraternity
 - Public key authentication, establishing key authenticity in public-key cryptography
 - Professional Karate Association
 - Primary knock-on atom, an atom that is displaced from its lattice site by irradiation
 - Painkiller Already, a podcast featuring FPSRussia
 - Pentax KA-mount, a camera lens mount
 
Non-Latin
- The Latin letters PKA are visually similar to the Cyrillic acronym РКА, the Russian Federal Space Agency
 
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