Polyvalence or polyvalent may refer to:
- Polyvalency (chemistry), chemical species, generally atoms or molecules, which exhibit more than one chemical valence
 - Polyvalence (music), the musical use of more than one harmonic function of a tonality simultaneously
 - Polyvalent antibody, a group of antibodies that have affinity for various antigens
 - Polyvalent logic, a form of many-valued logic or probabilistic logic
 - Polyvalent vaccine, a vaccine that can vaccinate a person against more than one strain of a disease
 - Sala Polivalentă (disambiguation), various stadiums in Romania commonly translated as Polyvalent Hall
 - Snake antivenom that contains neutralizing antibodies against two or more species of snakes
 
See also
- Bivalence, principle in logic that every declaration is either true or false
 - Monovalence (disambiguation)
 - Valence (disambiguation)
 
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