SSIM may refer to:
General
- Structural similarity in image processing
- South Sudan Independence Movement
- Saturated structured illumination microscopy
- Standard Schedules Information Manual in aviation
Educational institutions
- Swedish School in Moscow (Svenska Skolan i Moskva)
- S. S. Institute of Medical Sciences, a medical school in Davanagere, Karnataka, India
- Sri Siddhartha Institute of Management Studies in Tumkur, Karnataka, India
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