Semele is the mother of Dionysus in Greek mythology.
Semele may also refer to:
- Semele (Eccles), an opera by John Eccles
 - Semele (Handel), an opera by George Frideric Handel (given as an oratorio in its first run)
 - Sémélé, an opera by Marin Marais
 - Sémélé (Dukas cantata), a cantata by Paul Dukas
 - 86 Semele, an asteroid
 - Semele (plant), a genus of flowering plants
 - Semele (bivalve), a genus of bivalves
 - Radford Semele, a village in Warwickshire, England
 
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